Institute for Biocomputation and Physics of Complex Systems of the University of Zaragoza

1.- Design and optimization of drugs

  • Current clinical needs of new drugs
  • Stages of drug design and development
  • Therapeutic targets
  • Development process difficulties
  • Failure causes

2.- Strategies for new drug candidates’ identification

  • Protein folding and protein-ligand binding equilibrium
  • Molecular, cellular and in vivo assays
  • Experimental screening of chemical libraries
  • Computational screening of chemical libraries
  • Pharmacognosy: bioactive substances from natural sources
  • QSAR models: structure/activity/function relationships
  • Synthetic chemistry and medicinal chemistry

3.- From “in vitro” identification of bioactive substances to “in vivo” testing

  • Drug toxicity tests in cell and animal models
  • Bioavailability testing (ADME): Pharmacodynamics and pharmacokinetics
  • Special features of bioactive compound development in Veterinary, Cosmetics, Agriculture and Food Industry
  • Developing new drugs: Examples of small molecules identification

4.- Biomolecular engineering: Tools for protein and nucleic acids

  • Design, synthesis and combination of genes. Design of iRNA
  • Site directed and random mutagenesis
  • Protein expression systems
  • Protein modelling applications: Protein rational design

5.- Protein engineering

  • Improving protein stability
  • Improving protein solubility
  • Improving protein affinity
  • Improving protein fucntion
  • Development of new enzymes and receptors

6.- New products commercialization

  • Development of new drugs development: Examples.
  • Small molecules and biologics
  • Biotechnological market for bioactive compounds